Identification of Drug Target Properties and its validation on Helicobacter pylori

Uncategorized
  1. Nikita Chordia,
  2. Kapil Lakhawat,
  3. Anil Kumar*

Author Affiliations

  • School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, INDIA

Can J Biotech, Volume 1, Issue 1, Pages 44-49, DOI: 10.24870/cjb.2017-000101

Received: Oct 14, 2016; Revised: Jan 13, 2017; Accepted: Jan 24, 2017

Abstract

An analysis of 472 proteins taken from the drug target database and considered as bacterial drug targets has been carried out. A number of sequential properties viz. length, molecular weight, hydrophobicity, cellular localization, transmembrane helices, glycosylation and signal peptide were determined. Based on these properties, a range was set for each property and it was considered that a protein can be a drug target if that protein property comes in the same range. To validate, the method was applied to Helicobacter pylori having 1602 proteins. The properties were calculated for proteins from H. pylori and the range was applied to find the drug target. After analysis of the whole proteome, 5 proteins have been found to have all the properties in the range. The results were cross checked and it has been found that the resultant proteins are also drug targets for other pathogens. It indicated that the sequential properties of successful target help in finding the new drug target for the pathogen.

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