In silico analysis of SNPs of SYK gene Involved in Oral Cancer

  1. Sarita Swain1,
  2. Sucharita Balabantray1,
  3. Santosh kumar Behera2

Authors Affiliation(s)

  • 1Orissa University of engineering and technology, Bhubaneswar, INDIA
  • 2Regional Medical Research Centre, Bhubaneswar, INDIA

Can J Biotech, Volume 1, Special Issue-Supplement, Page 232, DOI:

Presenting author:


Oral cancer is the sixth most common cancer in the world. Oral cancer is the cancer of the oral cavity and pharynx, including cancer of the lip, tongue, salivary glands, gum, floor and other areas of the mouth. The aim of the study is to identify SNPs using dbSNP and predict the effect of mutation using Predict SNP. The association of genes is done by STRING. The disease and drugs associated with the genes are obtained from Webgestalt. The prediction of binding site is done by CASTp. The interaction of ligand and protein is done by using Autodock and Visualised through Discovery studio, pymol, Ligplot. From this report we found that oral cancer differs from person to person based on their genes and genetic interactions and expressions which recommend the clinicians to go for personalized medicine rather that generalized medicine for the patients with oral cancer. Seeking the importance of genetic background of oral cancer patients further studies can be done by mining of non-synonymous SNPs associated with genes for causing oral cancer.


  1. Berenson, J.R., Yang, J. and Mickel, R.A. (1989) Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas. Oncogene 4: 1111-1116.
  2. Riviere, A., Wickens, C. and Loning, T. (1990) Expression of c-erbB2 and c-myc in squamous epithelia and squamous cell carcinomas of the head and neck and the lower female genital tract. J Oral Pathol Med 19: 408-413. Crossref
  3. Somers, K.D., Cartwright, S.L. and Schechter, G.L. (1990) Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene 5: 915-920.
  4. Todd, R., Donoff, R.B. and Wong, D.T. (1997) The molecular biology of oral carcinogenesis: toward a tumor progression model. J Oral Maxillofac Surg 55: 613-623. Crossref
  5. Wong, D.T., Gallagher, G.T., Gertz, R., Chang, A.L. and Shklar, G. (1988) Transforming growth factor alpha in chemically transformed hamster oral keratinocytes. Cancer Res 48: 3130-3134.