Antimicrobial Peptides in Plants: Classes, Databases, and Importance

  1. Fatema Matkawala1,2
  2. Anand Nighojkar2,
  3. Anil Kumar1*

Authors Affiliation(s)

  • 1School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, INDIA
  • 2Maharaja Ranjit Singh College of Professional Sciences, Khandwa Road, Indore 452001, INDIA

Can J Biotech, Volume 3, Issue 2, Pages 158-168, DOI:

Received: Jul 12, 2019; Revised: Aug 19, 2019; Accepted: Aug 26, 2019


Plant antimicrobial peptides (AMPs) are diverse molecules crucial in host defense mechanisms. These natural compounds display broad-spectrum antimicrobial activities and also play a significant role as immune modulators and anti-infective agents. They are classified into different families like defensins, thionins, cyclotides, snakins, and several others, based on the variation in their structure, the composition of amino acids, number of disulfide bonds, and mechanism of action. The ascending number of drug- resistant plant and animal pathogens has pushed researchers to search for novel peptides, which can be utilized as alternatives to chemical antibiotics. In addition, the exhaustive genomic and proteomic data available on the cyberspace encourage the development of peptide libraries used for the prediction of unexplored peptides, thus saving time and cost for wet-lab experimentation. Understanding the insights of the structure and function of plant AMPs would offer excellent opportunities to expand their use as therapeutics in pharmaceutical and agricultural industries. This study reviewed the basis of plant AMPs, provided information on recent advancements in omic tools, and updated newly added peptides in the databases. The potential application of these peptides in human healthcare and agribusiness was also discussed.


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